Peptide Fz7-21

Research use only, not for human use.

Peptide Fz7-21 is a potent, selective peptide inhibitor of Frizzled 7 receptor, inhibits exogenous WNT3A stimulated Wnt-β-catenin signaling in HEK293 cells with IC50 of 100 nM.

Peptide Fz7-21 is a potent, selective peptide inhibitor of Frizzled 7 receptor, inhibits exogenous WNT3A stimulated Wnt-β-catenin signaling in HEK293 cells with IC50 of 100 nM; also blocks WNT3A-mediated stabilization of β-catenin in mouse L cells with IC50 of 50 nM; shows isoform-selective binding to the Fc-tagged FZD1, FZD2 and FZD7 CRDs with EC50 of 19-58 nM, whereas little to no binding to the FZD4, FZD5, FZD8, FZD9 or FZD10 CRDs; impaires Wnt signaling in cultured cells and stem cell function in intestinal organoids.

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Wnt/Notch/Hedgehog

Frizzled

Frizzled

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>98% (HPLC)

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Acetyl-Leu-Pro-Ser-Asp-Asp-Leu-Glu-Phe-Trp-Cys-His-Val-Met-Tyr-NH2

(-20℃)

With Ice Pack

≥ 2 years